Here's the biggest designer secret: when in doubt go big or go home. If you have a huge room, a larger piece will hold it's own; if the room is small the artwork becomes a statement. Either way I opt for large pieces over a collection of small ones more often than not because it creates a cohesive (read: no clutter) look.
All this said, some people LOVE the more-is-more aesthetic, so feel free to layer it on with a heavy hand! The beauty of designing your home is that you have the power to make it your's. If like me, you love a statement piece, then check out some of my favorite, affordable (under $200!) picks below.
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